Viruses—From pathogens to vaccine carriers

JC Small, HCJ Ertl - Current opinion in virology, 2011 - Elsevier
Vaccination is mankind's greatest public health success story. By now vaccines to many of
the viruses that once caused fatal childhood diseases are routinely used throughout the …

Recombinant transmissible vaccines will be intrinsically contained despite the ability to superinfect

JJ Bull, SL Nuismer, CH Remien… - Expert Review of …, 2024 - Taylor & Francis
Introduction Transmissible vaccines offer a novel approach to suppressing viruses in wildlife
populations, with possible applications against viruses that infect humans as zoonoses …

Is there a role for immunocontraception?

EA McLaughlin, RJ Aitken - Molecular and cellular endocrinology, 2011 - Elsevier
The world's population is continuing to grow at an alarming rate and yet no novel methods of
contraception have been introduced since 1960s. The paucity of our current contraceptive …

Recombinant HCMV and RHCMV vectors and uses thereof

L Picker, JA Nelson, K Frueh, MA Jarvis… - US Patent …, 2016 - Google Patents
The present invention relates to recombinant rhesus cytome galovirus (RhCMV) and human
cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen …

Natural killer cell dependent within-host competition arises during multiple MCMV infection: consequences for viral transmission and evolution

AR McWhorter, LM Smith, LL Masters, B Chan… - PLoS …, 2013 - journals.plos.org
It is becoming increasingly clear that many diseases are the result of infection from multiple
genetically distinct strains of a pathogen. Such multi-strain infections have the capacity to …

Recent advancements in understanding primary cytomegalovirus infection in a mouse model

K Bruce, J Ma, C Lawler, W Xie, PG Stevenson… - Viruses, 2022 - mdpi.com
Animal models that mimic human infections provide insights in virus–host interplay;
knowledge that in vitro approaches cannot readily predict, nor easily reproduce. Human …

[PDF][PDF] Wildlife population management: are contraceptive vaccines a feasible proposition

SK Gupta, V Minhas - Front Biosci (Schol Ed), 2017 - article.imrpress.com
To minimize human-animal conflicts for habitation and burden of zoonotic diseases, it is
imperative to develop new strategies for wildlife population management. In this direction …

Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife

J Yang, Z Zhou, G Li, Z Dong, Q Li, K Fu… - American Journal of …, 2023 - Wiley Online Library
The overabundant populations of wildlife have caused many negative impacts, such as
human‐wildlife conflicts and ecological degradation. The existing approaches like injectable …

CMV glycoproteins and recombinant vectors

L Picker, K Früh, S Hansen - US Patent 9,862,972, 2018 - Google Patents
Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen
that can repeatedly infect an organism while inducing a CD8+ T cell response to …

Could recombinant technology facilitate the realisation of a fertility-control vaccine for possums?

ML Cross, T Zheng, JA Duckworth… - New Zealand Journal of …, 2011 - Taylor & Francis
While lethal control remains the primary tool for possum control in New Zealand, there has
been substantial research effort over the last decade into controlling possum populations by …