Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

Emerging data indicate that neurological complications occur as a consequence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The blood–brain barrier …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

Intracerebral hemorrhage associated with thrombolytic therapy with tissue plasminogen
activator (tPA) in acute ischemic stroke continues to present a major clinical problem. Here …

Plasminogen is an abundant plasma protein that exists in various zymogenic forms.
Plasmin, the proteolytically active form of plasminogen, is known for its essential role in …

Rationale: Hemorrhagic complications represent a major limitation of intravenous
thrombolysis using tPA (tissue-type plasminogen activator) in patients with ischemic stroke …

The blood–brain barrier (BBB) consists of specific physical barriers, enzymes and
transporters, which together maintain the necessary extracellular environment of the central …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …