Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution

P Ma, X Liu, Z Xu, H Liu, X Ding, Z Huang, C Shi… - Cell Reports, 2022 - cell.com
Vertebrate evolution was accompanied by two rounds of whole-genome duplication
followed by functional divergence in terms of regulatory circuits and gene expression …

A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication

QJ Zhou, X Liu, L Zhang, R Wang, T Yin… - National Science …, 2022 - academic.oup.com
The process of domestication has led to dramatic differences in behavioral traits between
domestic dogs and gray wolves. Whole-genome research found that a class of putative …

Species-agnostic transfer learning for cross-species transcriptomics data integration without gene orthology

Y Park, NP Muttray, AC Hauschild - Briefings in Bioinformatics, 2024 - academic.oup.com
Novel hypotheses in biomedical research are often developed or validated in model
organisms such as mice and zebrafish and thus play a crucial role. However, due to …

Virology at Single Cell Resolution: Challenges and Opportunities for Single Cell RNA Sequencing in Studies of Viral Infection

PBO Cohen - 2022 - search.proquest.com
The ability to study viral infection with single cell resolution has been appreciated since at
least 1945. Recent developments in single-cell RNA sequencing (scRNAseq) have resulted …

[PDF][PDF] Improving Cell Type Matching across Species in scRNA-seq Data using Protein Embeddings and Transfer Learning

K Biharie - 2022 - repository.tudelft.nl
Knowing the relation between cell types is crucial for translating experimental results from
mice to humans. Establishing cell type matches, however, is hindered by the biological …