H3 K27M-altered glioma and diffuse intrinsic pontine glioma: Semi-systematic review of treatment landscape and future directions
M van den Bent, AM Saratsis, M Geurts… - Neuro …, 2024 - academic.oup.com
Abstract H3 K27M-mutant diffuse glioma is a recently identified brain tumor associated with
poor prognosis. As of 2016, it is classified by the World Health Organization as a distinct …
poor prognosis. As of 2016, it is classified by the World Health Organization as a distinct …
[HTML][HTML] Current status and advances to improving drug delivery in diffuse intrinsic pontine glioma
LM Arms, RJ Duchatel, ER Jackson… - Journal of Controlled …, 2024 - Elsevier
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …
Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity
X Xiang, Z Dai, B Luo, N Zhao, S Liu, J Sui… - Journal of Medicinal …, 2024 - ACS Publications
The activation of Homo sapiens Casein lysing protease P (HsClpP) by a chemical or genetic
strategy has been proved to be a new potential therapy in acute myeloid leukemia (AML) …
strategy has been proved to be a new potential therapy in acute myeloid leukemia (AML) …
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. Analysis …
pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment. Analysis …
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment
M Miciaccia, F Rizzo, A Centonze, G Cavallaro… - Pharmaceuticals, 2024 - mdpi.com
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare,
aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the …
aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the …
[HTML][HTML] ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells
J Cao, F Cao, C Wang, Z Jiao, Y You, X Wang, W Zhao - Neoplasia, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for
approximately 90% of all cases. ONC201, a member of the imipridone drug family, has …
approximately 90% of all cases. ONC201, a member of the imipridone drug family, has …
The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models
D de la Nava, I Ausejo-Mauleon, V Laspidea… - Neuro …, 2024 - academic.oup.com
Background Pediatric high-grade gliomas (pHGGs), including diffuse midline gliomas
(DMGs), are aggressive pediatric tumors with one of the poorest prognoses. Delta-24-RGD …
(DMGs), are aggressive pediatric tumors with one of the poorest prognoses. Delta-24-RGD …
Diffuse midline glioma, H3K27-altered: Illuminating the dark side of the moon
MD Dun, Y Odia, I Arrillaga-Romany - Neuro-oncology, 2024 - academic.oup.com
S90 Editorial underpinnings. Here, we outline the treatment landscape and future directions
of DMG research and patient care, including a review of the current state of biomarker …
of DMG research and patient care, including a review of the current state of biomarker …
GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas
Diffuse midline gliomas (DMGs) are lethal primary brain tumors in children. The imipridones
ONC201 and ONC206 induce mitochondrial dysfunction and have emerged as promising …
ONC201 and ONC206 induce mitochondrial dysfunction and have emerged as promising …
Harmaline and Human ClpP Activation for Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) Treatment
M Miciaccia, F Rizzo, A Centonze, G Cavallaro… - 2023 - preprints.org
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4-7 years, is a rare,
aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the …
aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the …