Ferroptosis in liver disease: new insights into disease mechanisms

J Wu, Y Wang, R Jiang, R Xue, X Yin, M Wu… - Cell death …, 2021 - nature.com
Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …

Ferroptosis-related small-molecule compounds in cancer therapy: strategies and applications

L Yin, P Liu, Y Jin, Z Ning, Y Yang, H Gao - European Journal of Medicinal …, 2022 - Elsevier
Ferroptosis is a novel type of regulated cell death which is driven by iron-dependent lipid
peroxidation and subsequent plasma membrane ruptures. Since ferroptosis was coined …

Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in melanoma

H Lv, X Liu, X Zeng, Y Liu, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) is the most lethal
skin cancer with increasing incidence. Regulated cell death plays an important role in …

Construction of a ferroptosis-related nine-lncRNA signature for predicting prognosis and immune response in hepatocellular carcinoma

Z Xu, B Peng, Q Liang, X Chen, Y Cai, S Zeng… - Frontiers in …, 2021 - frontiersin.org
Ferroptosis is an iron-dependent cell death process that plays important regulatory roles in
the occurrence and development of cancers, including hepatocellular carcinoma (HCC) …

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma

Y Lu, Q Yang, Y Su, Y Ji, G Li, X Yang, L Xu, Z Lu… - Cell death & …, 2021 - nature.com
MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma
(NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly …

Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway

G Liu, C Wei, S Yuan, Z Zhang, J Li… - Phytotherapy …, 2022 - Wiley Online Library
Wogonoside (WG) is a flavonoid chemical component extracted from Scutellaria baicalensis,
which exerts therapeutic effects on liver diseases. Ferroptosis, a novel form of programmed …

Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients

D Wang, G Wei, J Ma, S Cheng, L Jia, X Song… - BMC cancer, 2021 - Springer
Background Breast cancer (BRCA) is a malignant tumor with high morbidity and mortality,
which is a threat to women's health worldwide. Ferroptosis is closely related to the …

Development and validation of a combined ferroptosis and immune prognostic classifier for hepatocellular carcinoma

Y Liu, X Zhang, J Zhang, J Tan, J Li… - Frontiers in cell and …, 2020 - frontiersin.org
Background Immunotherapy and sorafenib exert anti-tumor effects via ferroptosis, but
reliable biomarkers for the individual treatment and prognosis prediction of hepatocellular …

An inflammatory response-related gene signature can impact the immune status and predict the prognosis of hepatocellular carcinoma

Z Lin, Q Xu, D Miao, F Yu - Frontiers in oncology, 2021 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which
makes the prognostic prediction challenging. As part of the active cross-talk between the …

Development and validation of a robust ferroptosis-related prognostic signature in lung adenocarcinoma

A Zhang, J Yang, C Ma, F Li, H Luo - Frontiers in Cell and …, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell
lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from …