Systemic lupus erythematosus (SLE) is a chronic multifactorial autoimmune disease that
affects many organs, including the kidney. Lupus nephritis (LN) is a common manifestation …

The immune system is guided by a series of checks and balances, a major component of
which is a large array of co-stimulatory and co-inhibitory pathways that modulate the host …

The immune system ensures optimum T-effector (Teff) immune responses against invading
microbes and tumor antigens while preventing inappropriate autoimmune responses …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. This
explains why podocyte injury is typically associated with nephrotic syndrome. The present …

Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical
trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to …

The influence of gut-leakage or gut-microbiota upon lupus progression was explored in 2
lupus mouse models. Pristane, administered in 4-wk-old wild-type (WT) female mice …

We have demonstrated previously that 17 β-estradiol (E2) treatment of BALB/c mice
transgenic for the heavy chain of a pathogenic anti-DNA Ab induces a lupus-like phenotype …

Renal ischemia is the most common cause of acute kidney injury (AKI) that might be
exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here …

Inflammation associated with bacterial infections is a risk factor for cancers in humans, yet its
role in breast cancer remains poorly understood. We have previously shown that innate …