Background: Despite an increase in the number of therapies available to treat patients with
immune thrombocytopenia (ITP), there are minimal data from randomized trials to assist …

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell
response, notably supported by splenic T follicular helper cells, that stimulates the …

Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

Platelet activation and subsequent thrombus formation at sites of vascular injury is crucial for
normal hemostasis, but it can also cause myocardial infarction and stroke. The initial capture …

Rituximab, an anti-CD20 monoclonal antibody, has been used to treat autoimmune
disorders such as idiopathic thrombocytopenic purpura (ITP). However, its mechanisms of …

Idiopathic (immune) thrombocytopenic purpura (ITP) is a common autoimmune disorder
resulting in isolated thrombocytopenia. ITP can present either alone (primary) or in the …

Objectives: The aim of this study was to explore the profile and function of CD4+ CD25+
regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients …

Recent evidence of distinct ITP pathophysiology has opened new exploratory avenues for
disease management. We will discuss the utility of investigations into these mechanisms of …

Immune thrombocytopenia (ITP) is a bleeding disorder characterized by antibody-opsonized
platelets being prematurely destroyed in the spleen, although some patients with ITP may …

Immune thrombocytopenia (ITP) is a common hematological manifestation of systemic lupus
erythematosus (SLE). The heterogeneity of its clinical characteristics and therapeutic …