The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications

MB Schulze, N Stefan - Nature Reviews Endocrinology, 2024 - nature.com
The concept of metabolic health, particularly in obesity, has attracted a lot of attention in the
scientific community, and is being increasingly used to determine the risk of cardiovascular …

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

G Xourafa, M Korbmacher, M Roden - Nature Reviews Endocrinology, 2024 - nature.com
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

P Akbari, OA Sosina, J Bovijn, K Landheer… - Nature …, 2022 - nature.com
Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent
of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 non …

The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean …

K Stefanakis, M Kokkorakis, CS Mantzoros - Metabolism, 2024 - Elsevier
Incretin receptor agonists have revolutionized the treatment of obesity, achieving up to 15–
25% weight loss in many patients, ie, at a rate approaching that achieved with bariatric …

Liver fat as risk factor of hepatic and cardiometabolic diseases

M Demir, SR Bornstein, CS Mantzoros… - Obesity …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …

[HTML][HTML] Sarcopenia in chronic liver disease: a metabolic perspective

R Kumar, SS Prakash, RN Priyadarshi… - Journal of clinical and …, 2022 - ncbi.nlm.nih.gov
Sarcopenia, a condition of low muscle mass, quality, and strength, is commonly found in
patients with chronic liver disease (CLD) and is associated with adverse clinical outcomes …

Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD

Z Zhang, G Ji, M Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide, affected by
both genetics and environment. Type 2 diabetes (T2D) stands as an independent …

Contribution of liver and pancreatic islet crosstalk to β-cell function/dysfunction in the presence of fatty liver

L López-Bermudo, A Luque-Sierra… - Frontiers in …, 2022 - frontiersin.org
Tissue-to-tissue crosstalk regulates organ function, according to growing data. This
phenomenon is relevant for pancreatic β-cells and the liver, as both tissues are involved in …

The effects of resistance training on myostatin and follistatin in adults: a systematic review and meta-analysis

M Khalafi, B Aria, ME Symonds, SK Rosenkranz - Physiology & behavior, 2023 - Elsevier
Introduction and aim Myostatin and follistatin are the main hormones for regulating muscle
mass, and previous research suggests they are modulated by resistance training. We …