KM Lelli, M Slattery, RS Mann - Annual review of genetics, 2012 - annualreviews.org
Regulation of gene expression in eukaryotes is an extremely complex process. In this review, we break down several critical steps, emphasizing new data and techniques that …
SJ Petesch, JT Lis - Trends in genetics, 2012 - cell.com
RNA polymerase II (Pol II) must break the nucleosomal barrier to gain access to DNA and transcribe genes efficiently. New single-molecule techniques have elucidated many …
J Xu, J Li, T Zhang, H Jiang… - Proceedings of the …, 2021 - National Acad Sciences
Specification of Sox2+ proneurosensory progenitors within otic ectoderm is a prerequisite for the production of sensory cells and neurons for hearing. However, the underlying molecular …
AL Hughes, OJ Rando - Annual review of biophysics, 2014 - annualreviews.org
It has been some 40 years since repeating subunits in eukaryotic chromatin, initially termed “nu bodies,” were described. Four decades of study have characterized the structural …
RNA polymerase II (PolII) transcribes RNA within a chromatin context, with nucleosomes acting as barriers to transcription. Despite these barriers, transcription through chromatin in …
Nucleosomal DNA is thought to be generally inaccessible to DNA-binding factors, such as micrococcal nuclease (MNase). Here, we digest Drosophila chromatin with high and low …
D Ganguli, RV Chereji, JR Iben, HA Cole… - Genome …, 2014 - genome.cshlp.org
RSC and SWI/SNF are related ATP-dependent chromatin remodeling machines that move nucleosomes, regulating access to DNA. We addressed their roles in nucleosome phasing …
N Nocetti, I Whitehouse - Genes & development, 2016 - genesdev.cshlp.org
Nucleosome repositioning at gene promoters is a fundamental aspect of the regulation of gene expression. However, the extent to which nucleosome repositioning is used within …
PD Talukdar, U Chatterji - Signal Transduction and Targeted Therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and …