Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants

Y Chen, MI Paramo, Y Zhang, L Yao… - Annual Review of …, 2023 - annualreviews.org
Despite accumulating evidence implicating noncoding variants in human diseases,
unraveling their functionality remains a significant challenge. Systematic annotations of the …

A generalizable framework to comprehensively predict epigenome, chromatin organization, and transcriptome

Z Zhang, F Feng, Y Qiu, J Liu - Nucleic Acids Research, 2023 - academic.oup.com
Many deep learning approaches have been proposed to predict epigenetic profiles,
chromatin organization, and transcription activity. While these approaches achieve …

A Comprehensive Evaluation of Self Attention for Detecting Feature Interactions

S Jabeen, A Ben-Hur - bioRxiv, 2024 - biorxiv.org
Using deep learning in computational biology requires methods that are able to extract
meaningful biological information from the trained models. Although deep learning models …