The clinical relevance of anti-DFS70 autoantibodies

K Conrad, N Röber, LEC Andrade, M Mahler - Clinical reviews in allergy & …, 2017 - Springer
Despite all the progress in the establishment of specific autoantibody assays, screening for
antinuclear antibodies (ANA) by indirect immunofluorescence on HEp-2 cells for quality …

Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases

M Mahler, JG Hanly, MJ Fritzler - Autoimmunity reviews, 2012 - Elsevier
The presence of anti-nuclear antibodies (ANA) is a hallmark of systemic autoimmune
rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay on HEp-2 cells is …

Pattern on the antinuclear antibody–HEp‐2 test is a critical parameter for discriminating antinuclear antibody–positive healthy individuals and patients with …

HA Mariz, EI Sato, SH Barbosa… - Arthritis & …, 2011 - Wiley Online Library
Objective To identify features of antinuclear antibody (ANA)–HEp‐2 test results that
discriminate ANA‐positive healthy individuals and patients with autoimmune rheumatic …

Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases

M Mahler, T Parker, CL Peebles, LE Andrade… - The Journal of …, 2012 - jrheum.org
Objective. Antinuclear antibodies (ANA) are a serological hallmark of systemic autoimmune
rheumatic diseases (SARD) such as systemic lupus erythematosus (SLE). While a number …

Antinuclear antibodies: a contemporary nomenclature using HEp-2 cells

AS Wiik, M Høier-Madsen, J Forslid, P Charles… - Journal of …, 2010 - Elsevier
The choice of terms used to describe indirect immunofluorescence (IIF) staining patterns of
autoantibodies binding to HEp-2 cells is at present quite varied and disordered because no …

The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding

RL Ochs, M Mahler, A Basu, L Rios-Colon… - Clinical and …, 2016 - Springer
Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …

[HTML][HTML] Antinuclear antibodies (ANA) as a criterion for classification and diagnosis of systemic autoimmune diseases

LEC Andrade, J Damoiseaux, D Vergani… - Journal of translational …, 2022 - Elsevier
The classification and diagnosis of systemic autoimmune diseases are frequently based on
a collection of criteria composed of clinical, laboratory, imaging, and pathology elements that …

The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp‐2 Cells for the Diagnosis of Systemic Autoimmune Diseases

M Mahler, MJ Fritzler - Journal of Immunology Research, 2012 - Wiley Online Library
Antinuclear antibodies (ANAs) are a serological hallmark in the diagnosis of systemic
autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay on …

Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions

GL Ortiz-Hernandez, ES Sanchez-Hernandez… - Autoimmunity …, 2020 - Springer
The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs)
presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic …

Anti-DFS70 antibodies: an update on our current understanding and their clinical usefulness

M Mahler, LE Andrade, CA Casiano… - Expert Review of …, 2019 - Taylor & Francis
Introduction: Anti-DFS70 antibodies and their clinical associations remain an immunological
paradox. Unlike other antinuclear antibodies (ANA), there is a growing body of evidence that …