The study of biological processes has driven the efforts of modern molecular biology to
unravel the microscopic capabilities of natural systems. Intrinsic to the experimental analysis …

The α-helix is the most commonly found natural secondary structure in proteins and is
intrinsic to many protein–protein interactions involved in important biological functions …

Over 40% of proteins in any eukaryotic genome encode intrinsically disordered regions (IDR
s) that do not adopt defined tertiary structures. Certain IDR s perform critical functions, but …

Synthetic biology may be viewed as an effort to establish, formalize, and develop an
engineering discipline in the context of biological systems. The ability to tune the properties …

Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for
genomic research and, potentially, drug discovery efforts for the treatment of …

We demonstrated the importance of maximized skeletal diversity of privileged substructures
for the construction of a drug-like small-molecule library through a series of high-throughput …

Low-density lipoprotein receptor (LDLR) is a cell-surface receptor that plays a central role in
regulating cholesterol levels. Increased levels of LDLR would lead to reduced cholesterol …

We have designed a 21-residue α-peptide that simultaneously recognizes two
decadeoxyoligothymidine (dT10) tracts to form triplexes with a peptide–DNA strand ratio of …

SynTEF1, a prototype synthetic genome reader/regulator (SynGR), was designed to target
GAA triplet repeats and restore the expression of frataxin (FXN) in Friedreich's ataxia …

The doublesex and mab-3 related transcription factor (Dmrt) gene family is known to be
related to the sexual regulators doublesex of arthropods and mab-3 of annelids and to hold …