Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

Modulation of the acetylation state of histones plays a pivotal role in the regulation of gene
expression. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from …

Histone deacetylase enzymes, which have been divided into three distinct structural classes,
operate by zinc-dependent (class I/II) or NAD-dependent (class III) mechanisms. Class I/II …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

The reversible acetylation of histones plays a critical proteins and small molecules is critical
for many other cellular processes. There is increasing evidence that the role in …

Use of human hepatocytes for therapeutic and drug discovery applications is hampered by
limited tissue source and the inability of hepatocytes to proliferate and maintain function long …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

Histones are small basic proteins that, by complexing wtih DNA, form the nucleosome core.
Repetitive units of this nucleosome led to the chromatin in which all the human genome is …