Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

The cohesin complex facilitates faithful chromosome segregation by pairing the sister
chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient …

Regions of the genome with the potential to form secondary DNA structures pose a frequent
and significant impediment to DNA replication and must be actively managed in order to …

Abstract Warsaw Breakage Syndrome (WABS) is a rare disorder related to cohesinopathies
and Fanconi anemia, caused by bi-allelic mutations in DDX11. Here, we report multiple …

The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of
DNA replication. However, its precise function and regulation in hepatocellular carcinoma …

The XPD family of helicases, that includes human disease-related FANCJ, DDX11 and
RTEL1, are Superfamily two helicases that contain an iron-sulphur cluster domain …

The alternative PCNA loader containing CTF18-DCC1-CTF8 facilitates sister chromatid
cohesion (SCC) by poorly defined mechanisms. Here we found that in DT40 cells, CTF18 …

DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles
DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The …

Homologous recombination (HR) is a major DNA double-strand break (DSB) repair pathway
of clinical interest because of treatment with poly (ADP-ribose) polymerase inhibitors …

DDX11 encodes an iron–sulfur cluster DNA helicase required for development, mutated,
and overexpressed in cancers. Here, we show that loss of DDX11 causes replication stress …