Hyaluronan (HA) is a linear glycosaminoglycan (GAG) of extracellular matrix (ECM)
synthesized by three hyaluronan synthases (HASes) at the plasma membrane using uridine …

Advances in cancer biology are revealing the importance of the cancer cell
microenvironment on tumorigenesis and cancer progression. Hyaluronan (HA), the main …

Neuroinflammation is initiated by activation of the brain's innate immune system in response
to an inflammatory challenge. Insufficient control of neuroinflammation leads to enhanced or …

Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …

Polyphenols, natural compounds rich in phenolic structures, are gaining prominence due to
their antioxidant, anti-inflammatory, antibacterial, and anticancer properties, making them …

Atherosclerosis, the main pathological basis of cardiovascular disease, is a chronic
inflammatory disease that severely affects the quality of human life. Resveratrol (Res) is a …

One of the main components of the extracellular matrix (ECM) of blood vessels is hyaluronic
acid or hyaluronan (HA). It is a ubiquitous polysaccharide belonging to the family of …

Abstract Pyrazolo [3, 4-d] pyrimidine had been attracted awesome interest due to its
pharmacological potential especially as an anticancer. Several mechanisms of action were …

Cancer is one of the leading causes of morbidity and mortality worldwide. Significant
improvements in the modern era of anticancer therapeutic strategies have increased the …

Coronary heart disease (CHD) with atherosclerosis is the leading cause of death worldwide.
ABCA1 and ABCG1 promote cholesterol efflux to suppress foam cell generation and reduce …