Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …

Ageing is characterized by the development of persistent pro-inflammatory responses that
contribute to atherosclerosis, metabolic syndrome, cancer and frailty,–. The ageing brain is …

Recent advances in mass spectrometry have expanded our knowledge of lipids and lipid
metabolic pathways involved in many (patho) physiological events. Targeted and non …

Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of
membranes, but it is unclear which biological processes are influenced by their regulation …

Cyclooxygenase, lipoxygenase, and epoxygenase derived oxylipins, especially
eicosanoids, play important roles in many physiological processes. Assessment of oxidized …

Anaphylaxis is a life-threatening hyperacute immediate hypersensitivity reaction. Classically,
it depends on IgE, FcεRI, mast cells, and histamine. However, anaphylaxis can also be …

Lipid autacoids derived from n-3/n-6 polyunsaturated fatty acids (PUFA) are some of the
earliest signals triggered by an inflammatory reaction. They are acting also as essential …

The acyl-chain composition of the major mammalian phospholipid phosphatidylcholine (PC)
is distinct in various tissues. Although it was classically suggested that PC diversity is …

Psoriasis is an inflammatory skin disease with accelerated epidermal cell turnover.
Neutrophil accumulation in the skin is one of the histological characteristics of psoriasis …

Combined liquid chromatography− electrospray ionization-tandem mass spectrometry (LC−
ESI-MS/MS) is a powerful method for the analysis of oxygenated metabolites of …