▪ Abstract Despite considerable evidence that neuronal activity influences the organization
and function of circuits in the developing and adult brain, the molecular signals that translate …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

During the development of the vertebrate nervous system, up to 50 percent or more of many
types of neurons normally die soon after they form synaptic connections with their target …

We have generated mice carrying a mutation of the gene encoding the low affinity NGF
receptor p75 NGFR by targeted mutation in embryonic stem cells. Mice homozygous for the …

The discovery of nerve growth factor (NGF) was a seminal event in history of research in
developmental neurobiology. The further discovery that NGF was just one of a family of …

Neurotrophic factors are proteins with considerable potential in the treatment of central
nervous system (CNS) diseases and traumatic injuries. However, a significant challenge to …

Background and Methods The nerve growth factor receptor is expressed in some
neuroblastomas, in which its primary component is encoded by the TRK proto-oncogene. To …

We have generated mice carrying a germline mutation in the tyrosine kinase catalytic
domain of the trkB gene. This mutation eliminates expression of gp145 trkB, a protein …

Neurotrophins bind to two structurally unrelated receptors, the trk tyrosine kinases and the
neurotrophin receptor p75 NTR. Ligand activation of these two types of receptor can lead to …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …