Structure and mutations of SARS-CoV-2 spike protein: a focused overview
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
[HTML][HTML] In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies
Summary SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern
regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we …
regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we …
[HTML][HTML] D614G mutation alters SARS-CoV-2 spike conformation and enhances protease cleavage at the S1/S2 junction
The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite …
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite …
Amyloidogenesis of SARS-CoV-2 spike protein
S Nystrom, P Hammarstrom - Journal of the American Chemical …, 2022 - ACS Publications
SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny
similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances …
similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances …
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2),
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …
[HTML][HTML] Cryo-EM structures of SARS-CoV-2 Omicron BA. 2 spike
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sub-
lineage has gained in proportion relative to BA. 1. Because spike (S) protein variations may …
lineage has gained in proportion relative to BA. 1. Because spike (S) protein variations may …
[HTML][HTML] The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes
SM Costello, SR Shoemaker, HT Hobbs… - Nature Structural & …, 2022 - nature.com
Current COVID-19 vaccines and many clinical diagnostics are based on the structure and
function of the SARS-CoV-2 spike ectodomain. Using hydrogen–deuterium exchange …
function of the SARS-CoV-2 spike ectodomain. Using hydrogen–deuterium exchange …
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses
To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …
[HTML][HTML] Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …