The lifespan human connectome project in aging: an overview

SY Bookheimer, DH Salat, M Terpstra, BM Ances… - Neuroimage, 2019 - Elsevier
Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease

R De Flores, R La Joie, G Chételat - Neuroscience, 2015 - Elsevier
Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of …

RNM Saleh, M Hornberger, CW Ritchie… - Alzheimer's research & …, 2023 - Springer
Background The risk of dementia is higher in women than men. The metabolic
consequences of estrogen decline during menopause accelerate neuropathology in …

[HTML][HTML] A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI

JE Iglesias, JC Augustinack, K Nguyen, CM Player… - Neuroimage, 2015 - Elsevier
Automated analysis of MRI data of the subregions of the hippocampus requires
computational atlases built at a higher resolution than those that are typically used in current …

Longitudinal changes in cortical thickness associated with normal aging

M Thambisetty, J Wan, A Carass, Y An, JL Prince… - Neuroimage, 2010 - Elsevier
Imaging studies of anatomic changes in regional gray matter volumes and cortical thickness
have documented age effects in many brain regions, but the majority of such studies have …

Automated segmentation of hippocampal subfields from ultra‐high resolution in vivo MRI

K Van Leemput, A Bakkour, T Benner, G Wiggins… - …, 2009 - Wiley Online Library
Recent developments in MRI data acquisition technology are starting to yield images that
show anatomical features of the hippocampal formation at an unprecedented level of detail …

Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments

EM Reiman, J Langbaum, AS Fleisher… - Journal of …, 2011 - content.iospress.com
There is an urgent need to find effective presymptomatic Alzheimer's disease (AD)
treatments that reduce the risk of AD symptoms or prevent them completely. It currently takes …

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease

SG Potkin, G Guffanti, A Lakatos, JA Turner, F Kruggel… - PloS one, 2009 - journals.plos.org
Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …

Human spatial navigation

AD Ekstrom, RS Rosenbaum, VD Bohbot, HJ Spiers - 2018 - torrossa.com
We would like to thank our families for their patience and understanding as we took time off
to work on this book. We dedicate this book to Dr. Howard Eichenbaum, a leader in the field …

Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects

X Hua, AD Leow, N Parikshak, S Lee, MC Chiang… - Neuroimage, 2008 - Elsevier
In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to
create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild …