[HTML][HTML] Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities

X Xu, B Sun, C Zhao - Neurobiology of Disease, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

The role of sesamin in targeting neurodegenerative disorders: a systematic review

MA Ghaderi, SA Emami… - Mini reviews in …, 2023 - ingentaconnect.com
Background: Neurodegenerative Diseases (NDs) are characterized by progressive neuronal
deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including …

Neuroprotective capability of narcissoside in 6-OHDA-exposed parkinson's disease models through enhancing the MiR200a/Nrf-2/GSH axis and mediating MAPK/Akt …

RH Fu, CW Tsai, SP Liu, SC Chiu, YC Chen… - Antioxidants, 2022 - mdpi.com
We assessed the antioxidant potential of narcissoside from Sambucus nigra flowers
(elderflowers) in Parkinson's disease models in vitro and in vivo. The results showed that …

Lavandula stoechas extract incorporated polylactic acid nanofibrous mats as an antibacterial and cytocompatible wound dressing

B Mutlu, F Çiftçi, CB Üstündağ, R Çakır-Koç - International Journal of …, 2023 - Elsevier
In recent years, great efforts have been devoted to the design and production of bioactive
wound dressings that promote skin regeneration and prevent infection. Many plant extracts …

Protective effects of 6‐gingerol on 6‐hydroxydopamine‐induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation

FS Rezazadeh‐Shojaee, E Ramazani… - … of Biochemical and …, 2022 - Wiley Online Library
Due to many therapeutic effects, Ginger (Zingiber officinale) is the most widely used spice
around the world, including in Iran. Due to its potent anti‐inflammatory and antioxidant …

Omarigliptin mitigates 6-Hydroxydopamine-or rotenone-induced oxidative toxicity in PC12 cells by antioxidant, anti-inflammatory, and anti-apoptotic actions

NA Gouda, J Cho - Antioxidants, 2022 - mdpi.com
Dipeptidyl peptidase-4 (DPP-4) inhibitors are reported to exhibit promising effects on several
pathological processes associated with Parkinson's disease (PD). To explore its …

Facile fabrication of drug-loaded PEGDA microcapsules for drug evaluation using droplet-based microchip

X Sun, Q Wu, W Li, X Gong, JY Ge, J Wu… - Chinese Chemical Letters, 2022 - Elsevier
Droplet-based microfluidic technology can be utilized as a microreactor to prepare novel
functional monodisperse microcapsules. In this study, a droplet-based microfluidic chip with …

[HTML][HTML] Chemical profiles and bioactivities of polyphenolic extracts of Lavandula stoechas L., Artemisia dracunculus L. and Ocimum basilicum L.

BN Silva, V Cadavez, C Caleja, E Pereira… - Food Chemistry, 2024 - Elsevier
This study assessed the chemical profiles and bioactivities of the infusions, decoctions and
hydroethanolic extracts of tarragon, basil and French lavender. The extracts were chemically …

Dietary flavonoids: Promising compounds for targeting α-synucleinopathy in Parkinson's disease

M Harati, Z Tayarani-Najaran, B Javadi - PharmaNutrition, 2023 - Elsevier
Background Alpha-synuclein (α-syn) aggregates contribute to neuronal damage and many
neurodegenerative disorders (NDs) which are known as α-synucleinopathies. Flavonoids …

In vitro and in vivo neuroprotective effect of novel mPGES-1 inhibitor in animal model of Parkinson's disease

S Yang, E Huh, GH Moon, J Ahn, J Woo, HS Han… - Bioorganic & Medicinal …, 2022 - Elsevier
Abstract mPGES-1 is found to be up-regulated in the dopaminergic neurons of the
substantia nigra pars compacta (SNpc) of postmortem brain tissue from Parkinson's disease …