Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …