C Yang, X Wang - Journal of Cell Biology, 2021 - rupress.org
Lysosomes are degradation centers and signaling hubs in cells and play important roles in cellular homeostasis, development, and aging. Changes in lysosome function are essential …
Exciting new discoveries have transformed the view of the lysosome from a static organelle dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …
C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …
FM Menzies, A Fleming, A Caricasole, CF Bento… - Neuron, 2017 - cell.com
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review …
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal physiological processes including removing of long lived, aggregated and misfolded …
S Sciarretta, M Forte, G Frati, J Sadoshima - Circulation research, 2018 - Am Heart Assoc
The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …
Y Rabanal-Ruiz, EG Otten… - Essays in biochemistry, 2017 - portlandpress.com
Cells and organisms must coordinate their metabolic activity with changes in their environment to ensure their growth only when conditions are favourable. In order to maintain …
SS Singh, S Vats, AYQ Chia, TZ Tan, S Deng, MS Ong… - Oncogene, 2018 - nature.com
Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and superfluous cellular …