Abstract Store-Operated Ca 2+ entry (SOCE) is recognized as a key mechanism in muscle
physiology necessary to refill intracellular Ca 2+ stores during sustained muscle activity. For …

Calsequestrin (CASQ) is the most abundant Ca 2+ binding protein localized in the
sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. The genome of vertebrates …

Tubular aggregate myopathy (TAM) is a heritable myopathy primarily characterized by
progressive muscle weakness, elevated levels of creatine kinase (CK), hypocalcemia …

Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of
sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA …

In the last decades the term Store-operated Ca 2+ entry (SOCE) has been used in the
scientific literature to describe an ubiquitous cellular mechanism that allows recovery of …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ influx mechanism triggered by
depletion of Ca2+ stores from the endoplasmic/sarcoplasmic reticulum (ER/SR). We recently …

Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function
mutations in the dystrophin gene, is characterized by progressive muscle degeneration and …

Calcium (Ca2+) entry units (CEUs) are junctions within the I band of the sarcomere between
stacks of sarcoplasmic reticulum (SR) cisternae and extensions of the transverse (T)-tubule …

Introduction: Ca2+ levels in adult skeletal muscle fibers are mainly controlled by excitation-
contraction (EC) coupling, a mechanism that translates action potentials in release of Ca2+ …

Over the past two decades, mounting evidence has demonstrated that a mechanism known
as store-operated Ca2+ entry (SOCE) plays a crucial role in sustaining skeletal muscle …