Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Cellular senescence plays a causal role in ageing and, in mice, depletion of p16INK4a-
expressing senescent cells delays ageing-associated disorders,. Adenosine deaminases …

We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …

High deviations resulting from prediction model, gender and population difference have
limited age estimation application of DNA methylation markers. Here we identified 2,957 …

Exceptional longevity represents an extreme phenotype. Current centenarians are survivors
of a cohort who display delayed onset of age-related diseases and/or resistance to …

RNA editing by adenosine deamination fuels the generation of RNA and protein diversity in
eukaryotes, particularly in higher organisms. This includes the recoding of translated exons …

Adenosine deaminases acting on RNA (ADARs) are the primary factors underlying
adenosine to inosine (A-to-I) editing in metazoans. Here we report the first global study of …

Numerous human diseases arise from alterations of genetic information, most notably DNA
mutations. Thought to be merely the intermediate between DNA and protein, changes in …

The field of the “epidemiology of longevity” has been expanding rapidly in recent years.
Several long-term cohort studies have followed older adults long enough to identify the most …