The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …

The physiological function of free fatty acids (FFAs) has long been regarded as indirect in
terms of their activities as educts and products in metabolic pathways. The observation that …

Fragment screening of a thermostabilized mGlu5 receptor using a high-concentration
radioligand binding assay enabled the identification of moderate affinity, high ligand …

Metabotropic glutamate receptor 5 (mGlu5) plays a key role in synaptic information storage
and memory, which is a well-known target for a variety of psychiatric and neurodegenerative …

Highlights•X-ray structures are now available for more than 60 ligands and 20
GPCRs.•Structures reveal details of ligand biding that could not be predicted.•Structure …

Two interesting new X-ray structures of negative allosteric modulator (NAM) ligands for the
mGlu5 receptor, M-MPEP (3) and fenobam (4), are reported. The new structures show how …

Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are promising targets for
multiple psychiatric and neurodegenerative disorders. Understanding the subtype selectivity …

The superfamily of G-protein-coupled receptors (GPCRs) represents the largest class of cell
surface receptors and, thus, a prominent family of drug targets. Recently, there has been …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of
neuritic plaques and neurofibrillary tangles. The impaired synaptic plasticity and dendritic …

Aqueous solutions of sodium L-glutamate (NaGlu) in the concentration range 0< c/M≤ 1.90
at 25° C were investigated by dielectric relaxation spectroscopy (DRS) and statistical …