The complex network of mTOR signalling in the heart
The mechanistic target of rapamycin (mTOR) integrates several intracellular and
extracellular signals involved in the regulation of anabolic and catabolic processes. mTOR …
extracellular signals involved in the regulation of anabolic and catabolic processes. mTOR …
Calreticulin: Endoplasmic reticulum Ca2+ gatekeeper
M Michalak - Journal of Cellular and Molecular Medicine, 2024 - Wiley Online Library
Endoplasmic reticulum (ER) luminal Ca2+ is vital for the function of the ER and regulates
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …
Characterization of ferroptosis-triggered pyroptotic signaling in heart failure
Pressure overload–induced cardiac hypertrophy is a common cause of heart failure (HF),
and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on …
and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on …
Integrated stress response couples mitochondrial protein translation with oxidative stress control
Background: The integrated stress response (ISR) is an evolutionarily conserved process to
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …
ATF4 protects the heart from failure by antagonizing oxidative stress
Background: Cellular redox control is maintained by generation of reactive oxygen/nitrogen
species balanced by activation of antioxidative pathways. Disruption of redox balance leads …
species balanced by activation of antioxidative pathways. Disruption of redox balance leads …
Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
SP Sajuthi, JL Everman, ND Jackson, B Saef… - Nature …, 2022 - nature.com
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide
association study for asthma by combining RNA-seq data from the nasal airway epithelium …
association study for asthma by combining RNA-seq data from the nasal airway epithelium …
Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress
response, and cell growth. However, its contribution to cardiac hypertrophic growth and …
response, and cell growth. However, its contribution to cardiac hypertrophic growth and …
Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress
The heart manifests hypertrophic growth in response to high blood pressure, which may
decompensate and progress to heart failure under persistent stress. Metabolic remodeling is …
decompensate and progress to heart failure under persistent stress. Metabolic remodeling is …
[HTML][HTML] FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
H Herrema, D Guan, JW Choi, X Feng… - Cell metabolism, 2022 - cell.com
Chronic endoplasmic reticulum (ER) stress and sustained activation of unfolded protein
response (UPR) signaling contribute to the development of type 2 diabetes in obesity. UPR …
response (UPR) signaling contribute to the development of type 2 diabetes in obesity. UPR …
PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart
Background: Metabolic remodeling precedes most alterations during cardiac hypertrophic
growth under hemodynamic stress. The elevation of glucose utilization has been recognized …
growth under hemodynamic stress. The elevation of glucose utilization has been recognized …