[HTML][HTML] Tumor-and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes
S Heeke, CM Gay, MR Estecio, H Tran, BB Morris… - Cancer cell, 2024 - cell.com
Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct
transcriptional subtypes, but implementing subtyping in the clinic has remained challenging …
transcriptional subtypes, but implementing subtyping in the clinic has remained challenging …
[HTML][HTML] Plasma cell-free tumor methylome as a biomarker in solid tumors: biology and applications
DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …
[HTML][HTML] Tissue and circulating biomarkers of benefit to immunotherapy in extensive-stage small cell lung cancer patients
M Lorenzi, MV Resi, L Bonanno, S Frega… - Frontiers in …, 2024 - frontiersin.org
Extensive stage-Small-Cell Lung Cancer (ES-SCLC) is an aggressive cancer with dismal
prognosis. The addition of immune-checkpoint inhibitors (ICIs) to platinum-based …
prognosis. The addition of immune-checkpoint inhibitors (ICIs) to platinum-based …
[HTML][HTML] Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling
T El Zarif, CB Meador, X Qiu, JH Seo… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: Histologic transformation to small cell lung cancer (SCLC) is a mechanism of
treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma …
treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma …
[HTML][HTML] Epigenetic modifications of cfDNA in liquid biopsy for the cancer care continuum
J Wong, R Muralidhar, L Wang, CC Huang - Biomedical Journal, 2024 - Elsevier
This review provides a comprehensive overview of the latest advancements in the clinical
utility of liquid biopsy, with a particular focus on epigenetic approaches aimed at overcoming …
utility of liquid biopsy, with a particular focus on epigenetic approaches aimed at overcoming …
Cell-free DNA methylation in the clinical management of lung cancer
The clinical use of cell-free DNA (cfDNA) methylation in managing lung cancer depends on
its ability to differentiate between malignant and healthy cells, assign methylation changes to …
its ability to differentiate between malignant and healthy cells, assign methylation changes to …