Regulated production of reactive oxygen species (ROS)/reactive nitrogen species (RNS)
adequately balanced by antioxidant systems is a prerequisite for the participation of these …

Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on
multiple organ systems. In this review, we summarize major leptin signaling pathways …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

One of the most profound challenges facing public health and public health policy in
Western society is the increased incidence and prevalence of both overweight and obesity …

Background—Obesity may alter vascular endothelial cell protein expression (VECPE) of
molecules that influence susceptibility to atherosclerosis. Methods and Results …

Two-thirds of adults in the US are overweight or obese, and another 26 million have type 2
diabetes (T2D). Patients with diabetes and/or the metabolic syndrome have a significantly …

Hemodynamic actions of insulin depend largely on the hormone's ability to stimulate
synthesis and release of endothelial mediators, whose balanced activity ensures dynamic …

Aims/hypothesis Obesity is an independent risk factor for heart diseases but the underlying
mechanism is not clear. This study examined cardiac contraction, oxidative stress, oxidative …

Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related
marker induced in cardiovascular diseases and is believed to represent a possible link …

Insulin resistance, a hallmark of metabolic disorders, is a risk factor for diabetes and
cardiovascular disease. Impairment of insulin responsiveness in vascular endothelium …