Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …

The induced pluripotent stem cell (i PSC) technology is instrumental in advancing the fields
of disease modeling and cell transplantation. We herein discuss the various issues …

Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …

The synaptic vesicle glycoprotein 2A (SV2A) is found in secretory vesicles in neurons and
endocrine cells. PET with a selective SV2A radiotracer will allow characterization of drugs …

Introduction Machine learning capability holds promise to inform disease models, the
discovery and development of novel disease modifying therapeutics and prevention …

Studies of individuals with amnestic mild cognitive impairment (aMCI) have detected
hyperactivity in the hippocampus during task-related functional magnetic resonance imaging …

Berries are well-known fruits for their antioxidant effects due to their high content of
flavonoids, and quercetin is one of the potent bioactive flavonoids. Although oxidative stress …