Emerging technologies for molecular diagnosis of sepsis

M Sinha, J Jupe, H Mack, TP Coleman… - Clinical microbiology …, 2018 - Am Soc Microbiol
Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Matrix assisted laser desorption time of flight mass spectrometry (MALDI-TOF MS) in clinical microbiology

S Angeletti - Journal of microbiological methods, 2017 - Elsevier
The microbiological management of patients with suspected bacterial infection includes the
identification of the pathogen and the determination of the antibiotic susceptibility. These …

Prevalence and clinical significance of sterile intra‐amniotic inflammation in patients with preterm labor and intact membranes

R Romero, J Miranda… - American journal of …, 2014 - Wiley Online Library
Problem Inflammation and infection play a major role in preterm birth. The purpose of this
study was to (i) determine the prevalence and clinical significance of sterile intra‐amniotic …

Next-generation sequencing diagnostics of bacteremia in septic patients

S Grumaz, P Stevens, C Grumaz, SO Decker… - Genome medicine, 2016 - Springer
Background Bloodstream infections remain one of the major challenges in intensive care
units, leading to sepsis or even septic shock in many cases. Due to the lack of timely …

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

R Romero, J Miranda, P Chaemsaithong… - The journal of …, 2015 - Taylor & Francis
Objective: The objectives of this study were to:(1) determine the amniotic fluid (AF)
microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) …

[HTML][HTML] Microbial diagnosis of bloodstream infection: towards molecular diagnosis directly from blood

O Opota, K Jaton, G Greub - Clinical microbiology and infection, 2015 - Elsevier
When a bloodstream infection (BSI) is suspected, most of the laboratory results—
biochemical and haematologic—are available within the first hours after hospital admission …

[HTML][HTML] Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques

R Romero, J Miranda, JP Kusanovic… - Journal of perinatal …, 2015 - degruyter.com
Introduction: The objectives of this study were: 1) to determine the amniotic fluid (AF)
microbiology of patients with the diagnosis of clinical chorioamnionitis at term using both …

Microbiota-immune interaction in the pathogenesis of gut-derived infection

C Wang, Q Li, J Ren - Frontiers in immunology, 2019 - frontiersin.org
Gut-derived infection is among the most common complications in patients who underwent
severe trauma, serious burn, major surgery, hemorrhagic shock or severe acute pancreatitis …

Effective use of mass spectrometry in the clinical laboratory

PJ Jannetto, RL Fitzgerald - Clinical chemistry, 2016 - academic.oup.com
BACKGROUND Historically the success of mass spectrometry in the clinical laboratory has
focused on drugs of abuse confirmations, newborn screening, and steroid analysis. Clinical …

Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance

R Romero, J Miranda, T Chaiworapongsa… - The Journal of …, 2015 - Taylor & Francis
Objective: To determine the frequency and clinical significance of sterile and microbial-
associated intra-amniotic inflammation in asymptomatic patients with a sonographic short …