The role of gammaherpesviruses in cancer pathogenesis
Worldwide, one fifth of cancers in the population are associated with viral infections. Among
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
KSHV LANA—the master regulator of KSHV latency
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
Mitotic spindle disruption by alternating electric fields leads to improper chromosome segregation and mitotic catastrophe in cancer cells
M Giladi, RS Schneiderman, T Voloshin, Y Porat… - Scientific reports, 2015 - nature.com
Abstract Tumor Treating Fields (TTFields) are low intensity, intermediate frequency,
alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a …
alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a …
Polyploid giant cancer cells, a hallmark of oncoviruses and a new therapeutic challenge
G Herbein, Z Nehme - Frontiers in Oncology, 2020 - frontiersin.org
Tumors are renowned as intricate systems that harbor heterogeneous cancer cells with
distinctly diverse molecular signatures, sizes and genomic contents. Among those various …
distinctly diverse molecular signatures, sizes and genomic contents. Among those various …
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies
MAY Adell, TC Klockner, R Höfler… - Genes & …, 2023 - genesdev.cshlp.org
Both the presence of an abnormal complement of chromosomes (aneuploidy) and an
increased frequency of chromosome missegregation (chromosomal instability) are …
increased frequency of chromosome missegregation (chromosomal instability) are …
[HTML][HTML] Cullin-RING Ligase 5: Functional characterization and its role in human cancers
Abstract Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …
[HTML][HTML] Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma
Z Long, T Wu, Q Tian, LA Carlson, W Wang… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Abstract Budding Uninhibited By Benzimidazoles are a group of genes encoding proteins
that play central roles in spindle checkpoint during mitosis. Improper mitosis may lead to …
that play central roles in spindle checkpoint during mitosis. Improper mitosis may lead to …
Kaposi's sarcoma herpesvirus genome persistence
Kaposi's sarcoma-associated herpesvirus (KSHV) has an etiologic role in Kaposi's sarcoma,
primary effusion lymphoma, and multicentric Castleman's disease. These diseases are most …
primary effusion lymphoma, and multicentric Castleman's disease. These diseases are most …
GNA14, GNA11, and GNAQ mutations are frequent in benign but not malignant cutaneous vascular tumors
P Jansen, H Müller, GC Lodde, A Zaremba… - Frontiers in …, 2021 - frontiersin.org
Cutaneous vascular tumors consist of a heterogeneous group of benign proliferations,
including a range of hemangiomas and vascular malformations, as well as heterogeneous …
including a range of hemangiomas and vascular malformations, as well as heterogeneous …
Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: More than a key mediator of viral persistence
TF Schulz, A Freise, SC Stein - Current Opinion in Virology, 2023 - Elsevier
Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …