Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting

MA Rahim, N Jan, S Khan, H Shah, A Madni, A Khan… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the leading causes of death globally. Several studies,
efforts and treatment strategies have been put forth for the treatment of different types of …

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

RJ Gillies, D Verduzco, RA Gatenby - Nature Reviews Cancer, 2012 - nature.com
All malignant cancers, whether inherited or sporadic, are fundamentally governed by
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …

Recent advances in supramolecular activatable phthalocyanine-based photosensitizers for anti-cancer therapy

BD Zheng, J Ye, XQ Zhang, N Zhang… - Coordination Chemistry …, 2021 - Elsevier
Phthalocyanines, as an organic compound, are widely used in photodynamic therapy (PDT),
but they still have the defect of poor selectivity. By introducing the concept of activatable …

Recent advances in smart hydrogels for biomedical applications: From self-assembly to functional approaches

NN Ferreira, LMB Ferreira, VMO Cardoso… - European Polymer …, 2018 - Elsevier
This review discusses basic aspects used to control the architecture and functional
properties of smart hydrogels. The introduction briefly outlines what has been accomplished …

pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents

M Karimi, M Eslami… - Wiley …, 2016 - Wiley Online Library
In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/
endogenous stimuli including temperature, magnetic/electric field, mechanical force …

Tumor microenvironment targeted nanotherapy

C Fernandes, D Suares, MC Yergeri - Frontiers in pharmacology, 2018 - frontiersin.org
Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

Hypoxic tumor microenvironment: Opportunities to develop targeted therapies

A Patel, S Sant - Biotechnology advances, 2016 - Elsevier
In recent years, there has been great progress in the understanding of tumor biology and its
surrounding microenvironment. Solid tumors create regions with low oxygen levels …

Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis

MJ Oudin, VM Weaver - Cold Spring Harbor symposia on …, 2016 - symposium.cshlp.org
Cancer metastasis requires the invasion of tumor cells into the stroma and the directed
migration of tumor cells through the stroma toward the vasculature and lymphatics where …

[HTML][HTML] pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery

Y Liu, W Wang, J Yang, C Zhou, J Sun - Asian Journal of Pharmaceutical …, 2013 - Elsevier
Most of the conventional chemotherapeutic agents used for cancer chemotherapy suffer
from multidrug resistance of tumor cells and poor antitumor efficacy. Based on physiological …