Modulation of host cell signaling during cytomegalovirus latency and reactivation
NA Smith, GC Chan, CM O'Connor - Virology Journal, 2021 - Springer
Background Human cytomegalovirus (HCMV) resides latently in cells of the myeloid
compartment, including CD34+ hematopoietic progenitor cells and circulating monocytes …
compartment, including CD34+ hematopoietic progenitor cells and circulating monocytes …
Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions
IJ Groves, CM O'Connor - Journal of Virology, 2024 - journals.asm.org
Three-dimensional chromatin control of eukaryotic transcription is pivotal for regulating gene
expression. This additional layer of epigenetic regulation is also utilized by DNA viruses …
expression. This additional layer of epigenetic regulation is also utilized by DNA viruses …
The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC
D Maestri, G Napoletani, A Kossenkov… - Nucleic Acids …, 2023 - academic.oup.com
Epstein–Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its
chromatinized episomes with the host genome. EBV exhibits different latency-associated …
chromatinized episomes with the host genome. EBV exhibits different latency-associated …
Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes
J Mahmud, BW Geiler, J Biswas, MJ Miller, JE Myers… - Science …, 2024 - science.org
Establishing a nonproductive, quiescent infection within monocytes is essential for the
spread of human cytomegalovirus (HCMV). We investigated the mechanisms through which …
spread of human cytomegalovirus (HCMV). We investigated the mechanisms through which …
Host-encoded CTCF regulates human cytomegalovirus latency via chromatin looping
IJ Groves, SM Matthews… - Proceedings of the …, 2024 - National Acad Sciences
Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes life-long latent
infection in hematopoietic cells. While this infection is usually asymptomatic, immune …
infection in hematopoietic cells. While this infection is usually asymptomatic, immune …
Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency
AB Wass, BA Krishna, LE Herring, TSK Gilbert… - Science …, 2022 - science.org
Cytomegalovirus (CMV) reactivation from latency following immune dysregulation remains a
serious risk for patients, often causing substantial morbidity and mortality. Here, we …
serious risk for patients, often causing substantial morbidity and mortality. Here, we …
Latency-associated upregulation of SERBP1 is important for the recruitment of transcriptional repressors to the viral major immediate early promoter of human …
E Poole, J Sinclair - Frontiers in Microbiology, 2022 - frontiersin.org
Suppression of human cytomegalovirus (HCMV) major immediate early gene (IE)
expression from the viral major immediate early promoter (MIEP) is known to be crucial for …
expression from the viral major immediate early promoter (MIEP) is known to be crucial for …
Controlling Much? Viral Control of Host Chromatin Dynamics
LE Kelnhofer-Millevolte, EA Arnold… - Annual Review of …, 2024 - annualreviews.org
Viruses are exemplary molecular biologists and have been integral to scientific discovery for
generations. It is therefore no surprise that nuclear replicating viruses have evolved to …
generations. It is therefore no surprise that nuclear replicating viruses have evolved to …
NFκB and cyclic AMP response element sites mediate the valproic acid and UL138 responsiveness of the human Cytomegalovirus major immediate early enhancer …
ER Albright, RM Walter, RT Saffert… - Journal of Virology, 2023 - Am Soc Microbiol
The major immediate early enhancer and promoter (MIEP) of human cytomegalovirus
(HCMV) drives the transcription of the immediate early one (IE1) and IE2 genes, whose …
(HCMV) drives the transcription of the immediate early one (IE1) and IE2 genes, whose …
A Viral long non-coding RNA protects against cell death during human cytomegalovirus infection of CD14+ monocytes
MR Perera, KL Roche, EA Murphy, JH Sinclair - Viruses, 2022 - mdpi.com
Long non-coding RNA β2. 7 is the most highly transcribed viral gene during latent human
cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to …
cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to …