Mathematical analysis of chemical reaction systems

PY Yu, G Craciun - Israel Journal of Chemistry, 2018 - Wiley Online Library
The use of mathematical methods for the analysis of chemical reaction systems has a very
long history, and involves many types of models: deterministic versus stochastic, continuous …

Identifying parameter regions for multistationarity

C Conradi, E Feliu, M Mincheva… - PLoS computational …, 2017 - journals.plos.org
Mathematical modelling has become an established tool for studying the dynamics of
biological systems. Current applications range from building models that reproduce …

Persistence and permanence of mass-action and power-law dynamical systems

G Craciun, F Nazarov, C Pantea - SIAM Journal on Applied Mathematics, 2013 - SIAM
Persistence and permanence are properties of dynamical systems that describe the long-
term behavior of the solutions and in particular specify whether positive solutions approach …

Toric differential inclusions and a proof of the global attractor conjecture

G Craciun - arXiv preprint arXiv:1501.02860, 2015 - arxiv.org
The global attractor conjecture says that toric dynamical systems (ie, a class of polynomial
dynamical systems on the positive orthant) have a globally attracting point within each …

The neural ring: an algebraic tool for analyzing the intrinsic structure of neural codes

C Curto, V Itskov, A Veliz-Cuba, N Youngs - Bulletin of mathematical …, 2013 - Springer
Neurons in the brain represent external stimuli via neural codes. These codes often arise
from stereotyped stimulus-response maps, associating to each neuron a convex receptive …

A geometric approach to the global attractor conjecture

M Gopalkrishnan, E Miller, A Shiu - SIAM Journal on Applied Dynamical …, 2014 - SIAM
This paper introduces the class of strongly endotactic networks, a subclass of the endotactic
networks introduced by Craciun, Nazarov, and Pantea. The main result states that the global …

Multistationarity in structured reaction networks

A Dickenstein, MP Millan, A Shiu, X Tang - Bulletin of Mathematical …, 2019 - Springer
Many dynamical systems arising in biology and other areas exhibit multistationarity (two or
more positive steady states with the same conserved quantities). Although deciding …

Topological descriptors of the parameter region of multistationarity: Deciding upon connectivity

ML Telek, E Feliu - PLOS Computational Biology, 2023 - journals.plos.org
Switch-like responses arising from bistability have been linked to cell signaling processes
and memory. Revealing the shape and properties of the set of parameters that lead to …

Algebraic systems biology: a case study for the Wnt pathway

E Gross, HA Harrington, Z Rosen… - Bulletin of mathematical …, 2016 - Springer
Steady-state analysis of dynamical systems for biological networks gives rise to algebraic
varieties in high-dimensional spaces whose study is of interest in their own right. We …

On the persistence and global stability of mass-action systems

C Pantea - SIAM Journal on Mathematical Analysis, 2012 - SIAM
This paper concerns the long-term behavior of population systems, and in particular of
chemical reaction systems, modeled by deterministic mass-action kinetics. We approach two …