The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible
progress in treating the disease such that the mean survival age of individuals living with CF …

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene that encodes a cAMP …

Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated
for research purposes. Different species, including mice, rats, ferrets, rabbits, pigs, sheep …

Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number
of people worldwide. The lack of understanding surrounding the pathophysiology of the …

In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection,
inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary …

Asthma is described as a chronic inflammatory disorder of the conducting airways. It is
characterized by reversible airway obstruction, eosinophil and Th2 infiltration, airway hyper …

Existing animal models of cystic fibrosis (CF) have provided key insights into CF
pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or …

Simple Summary An increasing number of cancer patients are treated with proton therapy.
Nevertheless, there are still open questions that require preclinical studies, for example …

Background Honey is widely used in folk medicine to treat cough, fever, and inflammation. In
this study, the effect of aerosolised honey on airway tissues in a rabbit model of ovalbumin …

Bronchopulmonary dysplasia (BPD) is an important lung developmental pathophysiology
that affects many premature infants each year. Newborn animal models employing both …