Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

AJ Grossberg, LC Chu, CR Deig… - CA: a cancer journal …, 2020 - Wiley Online Library
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

Early detection of pancreatic cancer

SP Pereira, L Oldfield, A Ney, PA Hart… - The lancet …, 2020 - thelancet.com
Pancreatic ductal adenocarcinoma is most frequently detected at an advanced stage. Such
late detection restricts treatment options and contributes to a dismal 5-year survival rate of 3 …

European evidence-based guidelines on pancreatic cystic neoplasms

European Study Group on Cystic Tumours of the … - Gut, 2018 - gut.bmj.com
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are
lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of …

[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges

AD Singhi, EJ Koay, ST Chari, A Maitra - Gastroenterology, 2019 - Elsevier
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas

M Tanaka, C Fernández-del Castillo, T Kamisawa… - Pancreatology, 2017 - Elsevier
The management of intraductal papillary mucinous neoplasm (IPMN) continues to evolve. In
particular, the indications for resection of branch duct IPMN have changed from early …

Risk of neoplastic progression in individuals at high risk for pancreatic cancer undergoing long-term surveillance

MI Canto, JA Almario, RD Schulick, CJ Yeo, A Klein… - Gastroenterology, 2018 - Elsevier
Background & Aims Screening of individuals who have a high risk of pancreatic ductal
adenocarcinoma (PDAC), because of genetic factors, frequently leads to identification of …

Impact of endoscopic ultrasonography on diagnosis of pancreatic cancer

M Kitano, T Yoshida, M Itonaga, T Tamura… - Journal of …, 2019 - Springer
Accumulated evidence has revealed that endoscopic ultrasonography (EUS) has had a
great impact on the clinical evaluation of pancreatic cancers. EUS can provide high …

Long-term risk of malignancy in branch-duct intraductal papillary mucinous neoplasms

H Oyama, M Tada, K Takagi, K Tateishi, T Hamada… - Gastroenterology, 2020 - Elsevier
Background & Aims Long-term outcomes of patients with branch-duct intraductal papillary
mucinous neoplasms (IPMNs), particularly those after 5 years of surveillance, have not been …

Single-cell transcriptomics of pancreatic cancer precursors demonstrates epithelial and microenvironmental heterogeneity as an early event in neoplastic progression

V Bernard, A Semaan, J Huang, FA San Lucas… - Clinical Cancer …, 2019 - AACR
Purpose: Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive.
Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms (IPMNs) …

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

AD Singhi, K McGrath, RE Brand, A Khalid, HJ Zeh… - Gut, 2018 - gut.bmj.com
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …