Organization and regulation of gene transcription
P Cramer - Nature, 2019 - nature.com
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms
RG Roeder - Nature structural & molecular biology, 2019 - nature.com
The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes
represented a major turning point in the field that, with subsequent elucidation of the distinct …
represented a major turning point in the field that, with subsequent elucidation of the distinct …
Conservation between the RNA polymerase I, II, and III transcription initiation machineries
A Vannini, P Cramer - Molecular cell, 2012 - cell.com
Recent studies of the three eukaryotic transcription machineries revealed that all initiation
complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the …
complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the …
Transcription termination by nuclear RNA polymerases
P Richard, JL Manley - Genes & development, 2009 - genesdev.cshlp.org
Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
RNA polymerase I structure and transcription regulation
Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …
Structure of eukaryotic RNA polymerases
P Cramer, KJ Armache, S Baumli, S Benkert… - Annu. Rev …, 2008 - annualreviews.org
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein
machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we …
machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we …
Molecular structures of unbound and transcribing RNA polymerase III
Transcription of genes encoding small structured RNAs such as transfer RNAs,
spliceosomal U6 small nuclear RNA and ribosomal 5S RNA is carried out by RNA …
spliceosomal U6 small nuclear RNA and ribosomal 5S RNA is carried out by RNA …
Mutations of POLR3A encoding a catalytic subunit of RNA polymerase Pol III cause a recessive hypomyelinating leukodystrophy
Leukodystrophies are a heterogeneous group of inherited neurodegenerative disorders
characterized by abnormal white matter visible by brain imaging. It is estimated that at least …
characterized by abnormal white matter visible by brain imaging. It is estimated that at least …
The landscape of transcription errors in eukaryotic cells
Accurate transcription is required for the faithful expression of genetic information. To
understand the molecular mechanisms that control the fidelity of transcription, we used novel …
understand the molecular mechanisms that control the fidelity of transcription, we used novel …