Fragile X encompasses a range of genetic conditions, all of which result as a function of
changes within the FMR1 gene and abnormal production and/or expression of the FMR1 …

N-methyl-d-aspartate receptors (NMDA-Rs) are located at each synapse in the lower
auditory pathway of mammals and avians. Characterized by a slow and long-lasting …

Chronic pain is still a basic science and clinical challenge. Unraveling of the neurobiological
mechanisms involved in chronic pain will offer novel targets for the development of …

Information processing in the brain relies on precise timing of signal propagation. The highly
conserved neuronal network for computing spatial representations of acoustic signals …

Drugs targeting N-methyl-D-aspartate receptors (NMDARs) have been approved to treat
major depressive disorder (MDD); however, the presence of undesirable psychotomimetic …

Palmitoylation of NMDARs occurs at two distinct cysteine clusters in the carboxyl-terminus of
GluN2A and GluN2B subunits that differentially regulates retention in the Golgi apparatus …

Key points Hindbrain NMDA receptors play important roles in reflexive and behavioural
responses to vagal activation. NMDA receptors have also been shown to contribute to the …

Neuronal dendrites are structurally and functionally dynamic in response to changes in
afferent activity. The fragile X mental retardation protein (FMRP) is an mRNA binding protein …

Ultrafast and temporally precise action potentials (APs) are biophysical specializations of
auditory brainstem neurons; properties necessary for encoding sound localization and …

Topography in the avian cochlear nucleus magnocellularis (NM) is represented as gradually
increasing characteristic frequency (CF) along the caudolateral-to-rostromedial axis. In this …