Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis

Y Yuan, VF Cruzat, P Newsholme, J Cheng… - Mechanisms of ageing …, 2016 - Elsevier
Aging is a degenerative process associated with cumulative damage, which leads to cellular
dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also …

[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells

C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Possible role of miRNAs in pheochromocytoma pathology-Signaling pathways interaction

SY Elkhawaga, A Elshafei, MA Elkady, AM Yehia… - … -Research and Practice, 2023 - Elsevier
Pheochromocytoma (PCC) is a type of neuroendocrine tumor that originates from adrenal
medulla or extra-adrenal chromaffin cells and results in the production of catecholamine …

[HTML][HTML] A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

D Pamies, P Barrera, K Block, G Makri, A Kumar… - Altex, 2017 - ncbi.nlm.nih.gov
Human in vitro models of brain neurophysiology are needed to investigate molecular and
cellular mechanisms associated with neurological disorders and neurotoxicity. We have …

miR-34 miRNAs provide a barrier for somatic cell reprogramming

YJ Choi, CP Lin, JJ Ho, X He, N Okada, P Bu… - Nature cell …, 2011 - nature.com
Somatic reprogramming induced by defined transcription factors is a low-efficiency process
that is enhanced by p53 deficiency,,,,. So far, p21 is the only p53 target shown to contribute …

MiR-137: an important player in neural development and neoplastic transformation

E Mahmoudi, MJ Cairns - Molecular psychiatry, 2017 - nature.com
MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

GQ Sun, P Ye, K Murai, MF Lang, S Li, H Zhang… - Nature …, 2011 - nature.com
Abstract miR-137 is a brain-enriched microRNA. Its role in neural development remains
unknown. Here we show that miR-137 has an essential role in controlling embryonic neural …

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

AK Jain, K Allton, M Iacovino, E Mahen… - PLoS …, 2012 - journals.plos.org
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this
is strictly due to repression of proliferation remains a subject of debate. Here, we show that …

Myocardial AKT: the omnipresent nexus

MA Sussman, M Völkers, K Fischer… - Physiological …, 2011 - journals.physiology.org
One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2

N Zhu, D Zhang, H Xie, Z Zhou, H Chen, T Hu… - Molecular and cellular …, 2011 - Springer
Endothelial cells are the key components of vascular intima and play pivotal roles in
vasculogenesis, angiogenesis, and tumor growth. Using Northern blot and real-time PCR …