Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

V Eisner, M Picard, G Hajnóczky - Nature cell biology, 2018 - nature.com
Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes

A Agarwal, PH Wu, EG Hughes, M Fukaya… - Neuron, 2017 - cell.com
Astrocytes extend highly branched processes that form functionally isolated microdomains,
facilitating local homeostasis by redistributing ions, removing neurotransmitters, and …

Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance

J Rose, C Brian, A Pappa, MI Panayiotidis… - Frontiers in …, 2020 - frontiersin.org
In the brain, mitochondrial metabolism has been largely associated with energy production,
and its dysfunction is linked to neuronal cell loss. However, the functional role of …

Miro proteins coordinate microtubule‐and actin‐dependent mitochondrial transport and distribution

G López‐Doménech, C Covill‐Cooke… - The EMBO …, 2018 - embopress.org
In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

SM Raefsky, MP Mattson - Free Radical Biology and Medicine, 2017 - Elsevier
An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

[HTML][HTML] Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

KJ De Vos, M Hafezparast - Neurobiology of disease, 2017 - Elsevier
Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

Mitochondrial dynamics in neuronal injury, development and plasticity

KH Flippo, S Strack - Journal of cell science, 2017 - journals.biologists.com
Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

The tripartite glutamatergic synapse

U Lalo, W Koh, CJ Lee, Y Pankratov - Neuropharmacology, 2021 - Elsevier
Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

C Murphy-Royal, AD Johnston, AKJ Boyce… - Nature …, 2020 - nature.com
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring
changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte …