JAK/STAT signaling: molecular targets, therapeutic opportunities, and limitations of targeted inhibitions in solid malignancies

B Rah, RA Rather, GR Bhat, AB Baba… - Frontiers in …, 2022 - frontiersin.org
JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

Progress in the management of ovarian granulosa cell tumor: A review

J Li, R Chu, Z Chen, J Meng, S Yao… - Acta obstetricia et …, 2021 - Wiley Online Library
Ovarian granulosa cell tumor (GCT) is a rare, low‐grade malignant tumor that accounts for
70% of the sex cord‐stromal tumors. It has two histopathologic types with different clinical …

[HTML][HTML] Expression and molecular profiles of the AlkB family in ovarian serous carcinoma

Y Cai, G Wu, B Peng, J Li, S Zeng, Y Yan… - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases plays essential roles in
development of ovarian serous carcinoma (OV). However, the molecular profiles of AlkB …

A phase 2 study of anastrozole in patients with oestrogen receptor and/progesterone receptor positive recurrent/metastatic granulosa cell tumours/sex-cord stromal …

SN Banerjee, M Tang, RL O'Connell, K Sjoquist… - Gynecologic …, 2021 - Elsevier
Background Hormonal therapies are commonly prescribed to patients with metastatic
granulosa cell tumours (GCT), based on high response rates in small retrospective studies …

Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review

MT Pinto, G Eiras Martins, AGS Vieira, JMS Galvão… - Cancers, 2023 - mdpi.com
Simple Summary Because ovarian germ cell tumors (OGCTs) are rare tumors, our current
understanding of them is sparse; this is because few studies have investigated the …

[HTML][HTML] Ovarian cancer: molecular classification and targeted therapy

F Ravindran, B Choudhary - Ovarian Cancer-Updates in Tumour …, 2021 - intechopen.com
Ovarian cancer is the deadliest gynecological cancer among women with an overall 5-year
survival rate below 50% due to its asymptomatic nature, diagnosis at advanced stages, and …

Delivery of SIRT1 by cancer-associated adipocyte-derived extracellular vesicles regulates immune response and tumorigenesis of ovarian cancer cells

Q Zheng, X Du, J Zhang, Y Liu, W Dong, X Dai… - Clinical and Translational …, 2024 - Springer
Purpose This study intends to investigate the possible molecular mechanism of immune
response and tumorigenesis in ovarian cancer cells, mediated by sirtuin 1 (SIRT1) …

Biosensors for cancer detection: A review

S Sarkar, S Hazra, S Patra, M Gogoi - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
The different types of biosensors and their critical applications across multiple domains for
cancer detection have been analyzed in this review. The biosensors have been categorized …

SWOG/NCI Phase II Dual Anti-CTLA-4/PD-1 Blockade in Rare Tumors (DART): Non-Epithelial Ovarian Cancer

YK Chae, M Othus, SP Patel, KJ Wilkinson… - Clinical Cancer …, 2024 - aacrjournals.org
Background: The role of dual checkpoint inhibition in advanced rare/ultra-rare non-epithelial
ovarian cancers (NEOCs) is yet to be explored. Methods: DART is a prospective, multicenter …

(In) distinctive role of long non-coding RNAs in common and rare ovarian cancers

M Sabol, J Calleja-Agius, R Di Fiore, S Suleiman… - Cancers, 2021 - mdpi.com
Simple Summary Ovarian cancers (OCs) are the most lethal form of gynecological tumors.
The commonest are high-grade serous OCs, while rare OCs originate from many different …