Clinical and translational research has played a major role in advancing our understanding
of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms …

Pharmacological and cellular treatment of cancer is changing dramatically with benefits for
patient outcome and comfort, but also with new toxicity profiles. The majority of adverse …

Intervertebral disc degeneration is highly prevalent within the elderly population and is a
leading cause of chronic back pain and disability. Due to the link between disc degeneration …

Coronavirus disease 2019 (COVID-19) represents a public health crisis of pandemic
proportions. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Cancer therapies can lead to a broad spectrum of cardiovascular complications. Among
these, cardiotoxicities remain of prime concern, but vascular toxicities have emerged as the …

Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …

Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on
case reports and small series, and was largely ineffectual. As a deeper understanding of the …

Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of
pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterioles leading to the …