HLA class I molecules as immune checkpoints for NK cell alloreactivity and anti-viral immunity in kidney transplantation

B Duygu, TI Olieslagers, M Groeneweg… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are innate lymphocytes that can kill diseased-or virally-infected cells,
mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines …

HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus

EC Castelli, P Gerasimou, MA Paz, J Ramalho… - Molecular …, 2017 - Elsevier
The HLA-G molecule presents immunomodulatory properties that might inhibit immune
responses when interacting with specific Natural Killer and T cell receptors, such as …

Worldwide HLA‐E nucleotide and haplotype variability reveals a conserved gene for coding and 3′ untranslated regions

LP Felício, IOP Porto, CT Mendes‐Junior… - Tissue …, 2014 - Wiley Online Library
The human leukocyte antigen‐E (HLA‐E) locus is a human major histocompatibility complex
(MHC) gene associated with immune‐modulation and suppression of the immune response …

HLA-E coding and 3′ untranslated region variability determined by next-generation sequencing in two West-African population samples

EC Castelli, CT Mendes-Junior, A Sabbagh… - Human Immunology, 2015 - Elsevier
HLA-E is a non-classical Human Leucocyte Antigen class I gene with immunomodulatory
properties. Whereas HLA-E expression usually occurs at low levels, it is widely distributed …

New insights in HLA‐E polymorphism by refined analysis of the full‐length gene

TI Olieslagers, CEM Voorter, M Groeneweg, Y Xu… - Hla, 2017 - Wiley Online Library
Background Human leukocyte antigen (HLA)‐E is a non‐classical HLA class I molecule that
plays a role in both the innate and the adaptive immune response through interaction with …

HLA-E, HLA-F and HLA-G—the non-classical side of the MHC cluster

I Foroni, AR Couto, BF Bettencourt… - HLA and Associated …, 2014 - books.google.com
Traditionally, the MHC is divided into the classes containing groups of genes with related
functions; the MHC class I and II genes encode for human leukocyte antigens (HLA) …

HLA-G,-E and-F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample

P Sonon, I Sadissou, L Tokplonou, KKG M'po… - Molecular …, 2018 - Elsevier
Abstract HLA-G/E/F genes exhibit immunomodulatory properties and are expressed in
placenta. Little attention has been devoted to the study of these genes in sub-Saharan …

HLA-E* 01: 01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E* 01: 03 allele increases the resistance to anti-HCV …

E Hosseini, ES Kazerooni, A Azarkeivan, Z Sharifi… - Human Immunology, 2022 - Elsevier
Background HLA-E binding to NKG2A/CD94 induces inhibitory signals that modulate NK
cells cytotoxicity against infected targets. HCV-derived peptides stabilize HLA-E molecule …

Human leukocyte antigen-e alleles are associated with hepatitis c virus, torque teno virus, and toxoplasma co-infections but are not associated with hepatitis b virus …

AA Prasetyo, R Dharmawan… - Journal of Global …, 2016 - journals.lww.com
Aims: The aim of this study was to analyze the association between HLA-E allelic variants
and infection with blood-borne pathogens such as hepatitis B virus (HBV), hepatitis C virus …

Clinical significance of HLA-E genotype and surface/soluble expression levels between healthy individuals and patients with acute leukemia

YP Xu, L Wieten, SX Wang, Y Cai… - Leukemia & …, 2019 - Taylor & Francis
Human leukocyte antigen (HLA)-E is a nonclassical HLA molecule with limited
polymorphisms. Genotype frequency and expression of HLA-E were examined here for the …