The burden of cancer is increasing globally. Several challenges facing its mainstream
treatment approaches have formed the basis for the development of targeted delivery …

Virotherapy research involves the development, exploration, and application of oncolytic
viruses that combine direct killing of cancer cells by viral infection, replication, and spread …

Systemic delivery of oncolytic adenovirus (oAd) for cancer gene therapy must overcome
several limitations such as rapid clearance from the blood, nonspecific accumulation in the …

Simple Summary If harnessed appropriately, oncolytic viruses offer significant potential as
anti-cancer agents. Such virotherapies can be engineered to replicate inside cancerous …

Simple Summary Current cancer therapies are insufficient to cure advanced malignancies
and cause off-target toxicity. Scientists have focused on developing new, more efficacious …

G-quadruplexes (G4s) are nucleic secondary structures characterized by G-tetrads. G4 motif
stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small …

Oncolytic adenoviruses (OAd) represent an attractive treatment option for cancer. Clinical
efficacy of commonly utilized human adenovirus type 5 (Ad5)-based oncolytic viruses is …

Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in various types of tumors
and functions as an oncogene; it could also be a potential target in tumor therapy …

Human Adenovirus type 6 (HAdV-C6) is a promising candidate for the development of
oncolytic vectors as it has low seroprevalence and the intrinsic ability to evade tissue …

Simple Summary Oncolytic adenoviruses are genetically engineered to selectively replicate
within cancer cells by exploiting their unique characteristics while sparing normal cells …