Individualizing patient treatment is a core objective of the medical field. Reaching this
objective has been elusive owing to the complex set of factors contributing to both disease …

Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease
modeling and the generation of tissue for renal replacement. Long-term application …

Metastasis has intrigued researchers for more than 100 years. Despite the development of
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …

Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body
to establish secondary tumors. Although this is an inefficient process, the consequences are …

Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches.
Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading …

The rapid turnover of the mammalian intestinal epithelium is supported by stem cells located
around the base of the crypt. In addition to the Lgr5 marker, intestinal stem cells have been …

In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a
set of defined mutations toward metastatic colorectal cancer (CRC). Here, we dissect this …

The emerging standard of care for patients with inoperable pancreatic cancer is a
combination of cytotoxic drugs gemcitabine and Abraxane, but patient response remains …