Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Phage Endolysins: Advances in the World of Food Safety

A Nazir, X Xu, Y Liu, Y Chen - Cells, 2023 - mdpi.com
As antimicrobial resistance continues to escalate, the exploration of alternative approaches
to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes …

Paving the way forward: Escherichia coli bacteriophages in a One Health approach

A Oliveira, C Dias, R Oliveira, C Almeida… - Critical Reviews in …, 2024 - Taylor & Francis
Escherichia coli is one of the most notorious pathogens for its ability to adapt, colonize, and
proliferate in different habitats through a multitude of acquired virulence factors. Its presence …

A Clostridioides difficile endolysin modulates toxin secretion without cell lysis

MM Awad, CD Suraweera, CJ Vidor, AY Ye-Lin… - Communications …, 2024 - nature.com
The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs)
responsible for disease symptoms, but the secretion mechanism is largely unknown …

Role of hypothetical protein PA1-LRP in antibacterial activity of endolysin from a new Pantoea phage PA1

Y Tian, X Xu, M Ijaz, Y Shen, MS Shahid… - Frontiers in …, 2024 - frontiersin.org
Introduction Pantoea ananatis has emerged as a significant plant pathogen affecting various
crops worldwide, causing substantial economic losses. Bacteriophages and their endolysins …

Novel endolysin LysMP for control of Limosilactobacillus fermentum contamination in small-scale corn mash fermentation

MH Patel, SY Lu, S Liu, CD Skory - Biotechnology for Biofuels and …, 2023 - Springer
Background Traditional bioethanol fermentation industries are not operated under strict
sterile conditions and are prone to microbial contamination. Lactic acid bacteria (LAB) are …

Influence of NaCl and pH on lysostaphin catalytic activity, cell binding, and bacteriolytic activity

S Konstantinova, A Grishin, A Lyashchuk… - Applied Microbiology …, 2022 - Springer
Peptidoglycan-degrading enzymes are a group of proteins intensively studied as novel
antibacterials, with some of them having reached pre-clinical and clinical stages of research …

PaP1, a broad-spectrum lysin-derived cationic peptide to treat polymicrobial skin infections

RD Heselpoth, CW Euler, VA Fischetti - Frontiers in Microbiology, 2022 - frontiersin.org
Most skin infections, including those complicating burns, are polymicrobial involving multiple
causative bacteria. Add to this the fact that many of these organisms may be antibiotic …

“Tear down that wall”—a critical evaluation of bioinformatic resources available for lysin researchers

S Bałdysz, R Nawrot, J Barylski - Applied and Environmental …, 2024 - Am Soc Microbiol
Lytic enzymes, or lysins for short, break down peptidoglycan and interrupt the continuity of
the cell wall, which, in turn, causes osmotic lysis of the bacterium. Their ability to destroy …

Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development

W Yamashita, S Ojima, A Tamura, AH Azam… - BioDesign …, 2024 - spj.science.org
The global increase in the prevalence of drug-resistant bacteria has necessitated the
development of alternative treatments that do not rely on conventional antimicrobial agents …