Embryonic stem cells (ESCs) have unlimited expansion potential and the ability to
differentiate into all somatic cell types for regenerative medicine and disease model studies …

The multipotent pancreatic progenitor cells (MPCs) co-expressing the transcription factors,
PDX1 and NKX6. 1, are the source of functional pancreatic β-cells. The aim of this study was …

Abstract Background Pancreatic progenitors (PPs) co-expressing the two transcription
factors (TFs) PDX1 and NKX6. 1 are recognized as the indispensable precursors of …

As cancer stem cells (CSCs) contribute to malignancy, metastasis, and relapse of cancers,
potential of compound in inhibition of CSCs has garnered most attention in the cancer …

Abstract Evolutionary Action analyses of The Cancer Gene Atlas data sets show that many
specific p53 missense and gain-of-function mutations are selectively overrepresented and …

Abstract p53 is a critical tumor suppressor in humans. It functions mostly as a transcriptional
factor and its activity is regulated by numerous post-translational modifications. Among …

Analyses of gene expression in single mouse embryonic stem cells (mESCs) cultured in
serum and LIF revealed the presence of two distinct cell subpopulations with individual gene …

Hepatic progenitor cells (HPCs) hold tremendous potential for liver regeneration, but their
well-known limitation of proliferation hampers their broader use. There is evidence that …

Abstract Development of effective therapeutic strategies to eliminate cancer stem-like cells
(CSCs), which play a major role in drug resistance and disease recurrence, is critical to …

Cancer dormancy is a stage in tumor progression in which residual disease remains occult
and asymptomatic for a prolonged period. Cancer cell dormancy is the main cause of cancer …