The dorsal striatum is a large forebrain region involved in action initiation, timing, control,
learning and memory. Learning and remembering skilled movement sequences requires the …

One key function of the brain is to control our body's movements, allowing us to interact with
the world around us. Yet, many motor behaviors are not innate but require learning through …

In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …

Chunking allows the brain to efficiently organize memories and actions. Although basal
ganglia circuits have been implicated in action chunking, little is known about how individual …

Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders,
including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 …

The learning of new skills is characterized by an initial phase of rapid improvement in
performance and a phase of more gradual improvements as skills are automatized and …

Learning new action sequences subserves a plethora of different abilities such as escaping
a predator, playing the piano, or producing fluent speech. Proper initiation and termination of …

Changes in cortical and striatal function underlie the transition from novel actions to refined
motor skills. How discrete, anatomically defined corticostriatal projections function in vivo to …

The ability to learn new skills and perfect them with practice applies not only to physical
skills but also to abstract skills, like motor planning or neuroprosthetic actions. Although …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …