Recently, a rapid increase in radiocarbon (14C) was observed in Japanese tree rings at AD
774/775. Various explanations for the anomaly have been offered, such as a supernova, a γ …

The actual coagulation status may be reliably measured using only highly sensitive global
functional tests; however, they are not numerous and all of them have disadvantages …

BACKGROUND: Hemophilia A (HA) patients with similar factor VIII levels can demonstrate
varying bleeding tendencies. In particular, 10–15% of all severe HA patients (FVIII: C< …

Abstract C1-inhibitor (C1INH) was shown to enhance thrombin generation (TG) in the
presence of thrombomodulin (TM) by reducing production of activated protein C. Because …

Background Metastatic tumors are a major source of morbidity and mortality for most
cancers. Interaction of circulating tumor cells with endothelium, platelets and neutrophils …

Objective Platelet-rich plasma (PRP) is typically isolated and applied immediately after
preparation, making it both a time-and labor-intensive addition to the operative procedure …

Refrigeration of platelets (4 C) provides the possibility of improving transfusion practice over
the current standard-of-care, room temperature (RT) storage. However, the increased level …

A new oral anticoagulant, dabigatran etexilate (DE, a prodrug of direct thrombin inhibitor
(DTI) dabigatran), has been used clinically to prevent thrombosis. The assessment of …

Background: The direct oral anticoagulant rivaroxaban inhibiting specifically activated factor
X (FXa) causes delayed thrombin generation (TG) as measured by calibrated automated …

Package inserts for C1-esterase inhibitor (C1INH) products include warnings for an elevated
risk of possible thrombosis in certain individuals, referring to thromboembolic events (TEEs) …