The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Second harmonic generation (SHG) microscopy is an important optical imaging technique in
a variety of applications. This article describes the history and physical principles of SHG …

Simple Summary A clinical decision and study design investigating the level and extent of
angiogenesis modulation aimed at vascular normalization without rendering tissues hypoxic …

Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …

Time-lapse fluorescence microscopy is one of the main tools used to image subcellular
structures in living cells. Yet for decades it has been applied primarily to in vitro model …

Speckle-based methods are popular non-invasive, label-free full-field optical techniques for
imaging blood flow maps at single vessel resolution with a high temporal resolution …

Intravital microscopy is an extremely powerful tool that enables imaging several biological
processes in live animals. Recently, the ability to image subcellular structures in several …

Conventional two-photon microscopy (TPM) is capable of imaging neural dynamics with
subcellular resolution, but it is limited to a field-of-view (FOV) diameter< 1 mm. Although …

Currently, most biological research relies on conventional experimental techniques that
allow only static analyses at certain time points in vitro or ex vivo. However, if one could …

Neurovascular coupling (NVC), or the adjustment of blood flow in response to local
increases in neuronal activity is a hallmark of healthy brain function, and the physiological …