The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …

Lung injury is the leading cause of death after thoracic surgery. Initially recognized after
pneumonectomy, it has since been described after any period of 1-lung ventilation (OLV) …

The endothelial glycocalyx has a profound influence at the vascular wall on the transmission
of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic …

BACKGROUND ARDS is a heterogeneous syndrome that encompasses lung injury from
both direct and indirect sources. Direct ARDS (pneumonia, aspiration) has been …

Vascular injury has emerged as a complication contributing to morbidity in coronavirus
disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component …

The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

Background Intravenous fluids, an essential component of sepsis resuscitation, may
paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models …

Blood urea nitrogen (BUN) and serum creatinine (SCr) are not very sensitive and specific
markers of kidney function in acute kidney injury (AKI) as they are influenced by many renal …

Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

Abstracts Background The number of studies measuring breakdown products of the
glycocalyx in plasma has increased rapidly during the past decade. The purpose of the …